The total iron-binding capacity (TIBC) test looks at how well the iron moves through your body. Knowing the molecular weight of the transferrin and that each molecule of transferrin can bind 2 atoms of iron, TIBC and transferrin concentration is interconvertible. A total iron-binding capacity (TIBC) test measures the blood's ability to attach itself to iron and transport it around the body. Your body uses iron to make hemoglobin, the protein in your red blood cells that carries oxygen throughout your body. A total iron binding capacity value above 450 mcg/dL usually means that there’s a low level of iron in your blood. Iron moves through the blood attached to a protein called transferrin. If you don't have enough iron, you may not have enough hemoglobin. The total iron-binding capacity (TIBC) of serum is a measure of total serum transferrin (apotransferrin, monotransferrin, diferric transferrin) concentration because insignificant amounts of plasma iron are bound to other proteins.
The total iron-binding capacity (TIBC) is the amount of iron needed to 100% saturate transferrin. Total iron binding capacity (TIBC) is a blood test to see if you have too much or too little iron in your blood.
The total iron-binding capacity (TIBC) can be indirectly determined using the sum of the serum iron and UIBC. A transferrin test is similar.
If you have iron deficiency (a lack of iron in your blood), your iron level will be low but your TIBC will be high. TIBC reflects iron status: levels are elevated when iron levels are low; therefore it is useful in the diagnosis and monitoring of iron deficiency anaemia and iron deficiency in late pregnancy. TIBC is calculated by measuring serum iron and serum unsaturated iron-binding capacity and summing these values. Iron is an important mineral that your body needs to stay healthy.
This test helps your health care provider know how well that protein can carry iron in your blood.
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